Performance of succinylacetone assays and their associated proficiency testing outcomes

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Performance of succinylacetone assays and their associated proficiency testing outcomes.

BACKGROUND Succinylacetone (SUAC) is the primary metabolic marker for hepatorenal tyrosinemia. MATERIALS AND METHODS We used results reported for dried-blood-spot proficiency testing (PT) specimens and hepatorenal tyrosinemia patients' newborn screening (NBS) samples to demonstrate analytic biases in SUAC recoveries and differences in presumptive clinical classifications. RESULTS SUAC recov...

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ژورنال

عنوان ژورنال: Clinical Biochemistry

سال: 2012

ISSN: 0009-9120

DOI: 10.1016/j.clinbiochem.2012.08.007